Like better native collagen than glucosamine

Assessment of the effectiveness of collagen preparations in osteoarthritis

detailed description

Osteoarthritis (OA) is a chronically progressive degenerative disease with thinning of cartilage in mobile joints that leads to friction between the bones and causes pain, stiffness, and abnormal movement. It is estimated that more than 20% of the population is affected beyond the age of 60 and is considered to be the leading cause of morbidity, disability and impairment of quality of life. In India, studies reported a prevalence of 22% to 39% in OA, the second most common rheumatological disorder. As global life expectancy increases, the prevalence of OA is expected to continue to increase, ultimately leading to a greater burden on OA in health care. Currently management has been largely palliative and focused on symptom relief. The principles of OA treatments are mainly to relieve pain and stiffness and maintain function. Current treatment guidelines recommend a combination of physical therapy and the use of analgesia with acetaminophen or NSAIDs and surgery if deemed necessary. While drugs slow the progression of OA and other inflammatory diseases, this has not been proven. There are currently disease-modifying agents available to treat knee OA. The majority of individuals are successfully treated with a combination of the above treatments, but there is still a significant group of patients for whom these treatments are not offered adequate relief. Additionally, there is still a lack of proven treatments to be effective in stopping or reversing the degenerative process. Also, there are significant side effects associated with the use of these drugs. As a result, OA sufferers have turned to natural nutraceuticals to ease their pain and discomfort. In recent years, several novel drugs have emerged as potential treatment alternatives to improve pain, stiffness, and function with the potential to alter the progression of the disease. These products are widely used because they are well tolerated and are believed to be safe. Among the OA sufferers, glucosamine and chondroitin are the most commonly used and have been shown to greatly reduce the pain associated with arthritis. From a Nutraceutical Perspective There is growing interest in collagen supplement as a solution for the treatment of OA. The collagen supplement has been extensively studied in both animals and humans. Among animal studies, one study in the rat model of OA reported several post-treatment benefits, indicating its potential for preventing joint deterioration in cartilage damage. In another study, the administration of a pig collagen supplement showed a significant reduction in pain intensity. A lower dosage regimen also showed significant pain reduction, which indicates its protective effect on the cartilage. In addition, several studies have evaluated the effectiveness and safety of collagen supplements in people who suffer from chronic OA. Crowley and colleagues showed that supplementing a collagen supplement for three months are more effective than the combination of glucosamine plus chondroitin. In another study, the collagen supplement was given for 6 months. Compared to glucosamine, pain, stiffness and physical function were significantly reduced. Hydrochloride plus chondroitin sulfate group of participants with knee OA. Based on the evidence available, it is clear that collagen supplement is effective in improving joint discomfort associated with OA. In addition, collagen products are also recognized by the U.S. Food Safety and Nutrition Administration Center as Safe Ingredients for Pharmaceuticals and Food. Hence, considering its symptomatic benefits, structural effects on cartilage, and its important role in bone structure, collagen supplement is viewed as a viable alternative for OA patients. Therefore, the present study aimed to evaluate the safety and effectiveness of a collagen supplement in participants with knee OA. Volunteer students are given a collagen supplement, a collagen product, for 12 weeks and rated as per study termed efficacy and safety variables. The effectiveness and effectiveness of collagen supplement is also compared with glucosamine HCL plus chondroitin sulfate and placebo according to the established study intervals.